Pub. Date : 2019
PMID : 30584141
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results showed that when pretreated with 3.0 mg/kg LPS, thioflavin S can be found in the brain bound to Abeta plaques in aged 5XFAD transgenic mice. | thioflavin T | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | Our results suggest that the BBB in aged 5XFAD mouse model is susceptible to increased permeability mediated by LPS, allowing for improved delivery of the small molecule thioflavin S to target Abeta plaques and SPIO nanoparticles, which are significantly larger than antibodies used in clinical trials for immunotherapy of AD. | thioflavin T | amyloid beta (A4) precursor protein | Mus musculus |