Title : Novel betulin derivatives inhibit IFN-γ and modulates COX-2 expression.

Pub. Date : 2020 Jun

PMID : 30580627






2 Functional Relationships(s)
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1 Among these BE derivatives, two (2a e 2c) were able to significantly decrease IFN-g (*p = 0.0391; **p = 0.0156) and 2c modulated the expression of COX-2 better than Dexamethasone (DEXA). Dexamethasone mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The presence of chorine in BE seems to be important for the ability of modulate COX-2 expression, since the ester chloride derivative 2c at 100 muM is more powerful inhibitor of COX-2 than DEXA. Dexamethasone mitochondrially encoded cytochrome c oxidase II Homo sapiens