Title : Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models.

Pub. Date : 2019 Feb 15

PMID : 30579954






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hexokinase 1 and 2 have been shown to inhibit Bak- and Bax-mediated apoptosis, leading us to combine the histone deacetylase inhibitor romidepsin with clotrimazole or bifonazole, two compounds that reportedly decrease mitochondrial localization of hexokinases. bifonazole hexokinase 1 Homo sapiens