Title : An N6-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.

Pub. Date : 2019 Feb

PMID : 30578766






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Methylation of the transited adenosine was catalyzed by methyltransferase like 3 (METTL3), and this m6A-RNA promoted a preferential pre-mRNA splicing; consequently, the produced p53 R273H mutant protein resulted in acquired multidrug resistance in colon cancer cells. Adenosine methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Homo sapiens
2 Methylation of the transited adenosine was catalyzed by methyltransferase like 3 (METTL3), and this m6A-RNA promoted a preferential pre-mRNA splicing; consequently, the produced p53 R273H mutant protein resulted in acquired multidrug resistance in colon cancer cells. Adenosine methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Homo sapiens