Title : An N6-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.

Pub. Date : 2019 Feb

PMID : 30578766






1 Functional Relationships(s)
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1 Furthermore, glycosphingolipids (particularly globotriaosylceramide) generated from serial ceramide glycosylation were seen to activate cSrc and beta-catenin signaling so as to upregulate METTL3 expression, in turn promoting expression of p53 R273H mutant protein, with consequent drug resistance. globotriaosylceramide SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens