Pub. Date : 2019 Apr
PMID : 30578419
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Serotonin transporter inhibition and 5-HT2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice. | Cocaine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 2 | Additionally, a cocaine analog (RTI-113) with greater selectivity for DAT over SERT retains locomotor activation in DAT Val559 mice. | Cocaine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 3 | Additionally, a cocaine analog (RTI-113) with greater selectivity for DAT over SERT retains locomotor activation in DAT Val559 mice. | Cocaine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 4 | Furthermore, genetic elimination of high-affinity cocaine interactions at SERT in DAT Val559 mice, or specific inhibition of 5-HT2C receptors in these animals, restored cocaine-induced locomotion, but did not restore cocaine-induced elevations of extracellular DA. | Cocaine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |