Pub. Date : 2019 Feb
PMID : 30576925
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of thioredoxin-dependent H2O2 removal sensitizes malignant B-cells to pharmacological ascorbate. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 2 | Here we present that thioredoxin antioxidant system plays a key role in the scavenging of extracellularly-generated H2O2 in malignant B-cells. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 3 | We show that inhibition of peroxiredoxin 1, the enzyme that removes H2O2 in a thioredoxin system-dependent manner, increases the sensitivity of malignant B-cells to L-ASC. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 4 | Moreover, we demonstrate that auranofin (AUR), the inhibitor of the thioredoxin system that is used as an antirheumatic drug, diminishes the H2O2-scavenging capacity of malignant B-cells and potentiates pharmacological ascorbate anticancer activity in vitro and in vivo. | Hydrogen Peroxide | thioredoxin | Homo sapiens |