Title : Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia.

Pub. Date : 2019 Apr

PMID : 30576866






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hypophosphatasia (HPP) features low tissue-nonspecific alkaline phosphatase (TNSALP) isoenzyme activity resulting in extracellular accumulation of its substrates including pyridoxal 5"-phosphate (PLP), the principal circulating form of vitamin B6, and inorganic pyrophosphate (PPi), a potent inhibitor of mineralization. Vitamin B 6 alkaline phosphatase, biomineralization associated Homo sapiens
2 Hypophosphatasia (HPP) features low tissue-nonspecific alkaline phosphatase (TNSALP) isoenzyme activity resulting in extracellular accumulation of its substrates including pyridoxal 5"-phosphate (PLP), the principal circulating form of vitamin B6, and inorganic pyrophosphate (PPi), a potent inhibitor of mineralization. Vitamin B 6 alkaline phosphatase, biomineralization associated Homo sapiens