Pub. Date : 2019 May
PMID : 30576222
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Klotho protein inhibits H2O2-induced oxidative injury in endothelial cells via regulation of PI3K/AKT/Nrf2/HO-1 pathways. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Klotho protein enhanced the antioxidant defense ability of the cells by activating the PI3K/AKT pathway, which upregulated the expression of Nrf2/HO-1, thereby inhibiting H2O2-induced oxidative damage. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Homo sapiens |