Title : Intravenous arsenic trioxide and all-trans retinoic acid as front-line therapy for low-risk acute promyelocytic leukemia.

Pub. Date : 2019 Feb

PMID : 30572725






1 Functional Relationships(s)
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1 INTRODUCTION: The outcome of acute promyelocytic leukemia (APL) has drastically improved following the identification of the PML-RARA oncogene as a key player in the pathogenesis of APL, and the subsequent introduction of all-trans retinoic acid (ATRA) as a therapeutic agent. Tretinoin PML nuclear body scaffold Homo sapiens