Title : Synthesis and Evaluation of the 4-Substituted 2-Hydroxy-5-Iodochalcones and Their 7-Substituted 6-Iodoflavonol Derivatives for Inhibitory Effect on Cholinesterases and β-Secretase.

Pub. Date : 2018 Dec 18

PMID : 30567381






1 Functional Relationships(s)
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1 Similarly docking studies predicted interaction of the most active compounds with both CAS and PAS of either AChE or BChE with mixed type of enzyme inhibition confirmed by kinetic studies. Calcium acetylcholinesterase (Cartwright blood group) Homo sapiens