Pub. Date : 2019 Sep
PMID : 30565018
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vitamin C Attenuates Sodium Fluoride-Induced Mitochondrial Oxidative Stress and Apoptosis via Sirt1-SOD2 Pathway in F9 Cells. | Ascorbic Acid | superoxide dismutase 2 | Homo sapiens |
| 2 | Knockdown of Sirt1 blocked the vitamin C-mediated reduction in mROS and apoptosis via inhibiting Sirt1-SOD2 signaling. | Ascorbic Acid | superoxide dismutase 2 | Homo sapiens |
| 3 | Importantly, sodium-dependent vitamin C transporter 2 (SVCT-2) siRNA was found to partially block the ability of vitamin C to promote Sirt1/SOD2 signaling. | Ascorbic Acid | superoxide dismutase 2 | Homo sapiens |
| 4 | In summary, our data indicate that Sirt1 plays a pivotal role in the ability of vitamin C to stimulate SOD2 activity and attenuate mitochondrial oxidative stress, which partially through vitamin C receptor in NaF-induced F9 cells injury. | Ascorbic Acid | superoxide dismutase 2 | Homo sapiens |