Pub. Date : 2019 Feb
PMID : 30557824
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1beta and IL-18 production. | Sirolimus | interleukin 1 beta | Mus musculus |
| 2 | However, it is not clear whether the mTOR specific inhibitor rapamycin can attenuate lipopolysaccharide (LPS)-induced ALI by modulating IL-1beta and IL-18 production. | Sirolimus | interleukin 1 beta | Mus musculus |
| 3 | In this study, we found that rapamycin ameliorated LPS-induced ALI by inhibiting NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated IL-1beta and IL-18 secretion. | Sirolimus | interleukin 1 beta | Mus musculus |