Pub. Date : 2018 Dec
PMID : 30556042
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | More than 90% of 20-month-old whole-body Fxr-null mice had hepatic tumors with enhanced hepatic expression of myelocytomatosis oncogene (Myc) and cyclin-dependent kinase 4 (Cdk4) messenger RNAs (mRNAs) and elevated serum taurocholate (TCA) and tauromuricholate (TMCA) and their respective unconjugated derivatives. | Taurocholic Acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 2 | More than 90% of 20-month-old whole-body Fxr-null mice had hepatic tumors with enhanced hepatic expression of myelocytomatosis oncogene (Myc) and cyclin-dependent kinase 4 (Cdk4) messenger RNAs (mRNAs) and elevated serum taurocholate (TCA) and tauromuricholate (TMCA) and their respective unconjugated derivatives. | Taurocholic Acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 3 | Treatment with TCA induced Myc expression in Fxr-null cultured primary mouse hepatocytes but not in wild-type (WT) mouse hepatocytes, demonstrating that the combination of hepatocyte FXR disruption with elevated TCA is required for Myc induction and ensuing age-dependent hepatocarcinogenesis in Fxr-null mice. | Taurocholic Acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 4 | Treatment with TCA induced Myc expression in Fxr-null cultured primary mouse hepatocytes but not in wild-type (WT) mouse hepatocytes, demonstrating that the combination of hepatocyte FXR disruption with elevated TCA is required for Myc induction and ensuing age-dependent hepatocarcinogenesis in Fxr-null mice. | Taurocholic Acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 5 | Treatment with TCA induced Myc expression in Fxr-null cultured primary mouse hepatocytes but not in wild-type (WT) mouse hepatocytes, demonstrating that the combination of hepatocyte FXR disruption with elevated TCA is required for Myc induction and ensuing age-dependent hepatocarcinogenesis in Fxr-null mice. | Taurocholic Acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |