Title : Decreased PKG transcription mediated by PI3K/Akt/FoxO1 pathway is involved in the development of nitroglycerin tolerance.

Pub. Date : 2019 Jan 22

PMID : 30554658






4 Functional Relationships(s)
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1 Decreased PKG transcription mediated by PI3K/Akt/FoxO1 pathway is involved in the development of nitroglycerin tolerance. Nitroglycerin thymoma viral proto-oncogene 1 Mus musculus
2 The present study is to determine whether PI3K/Akt pathway in vascular smooth muscle cells is involved in nitroglycerin (NTG) tolerance and the underlying mechanism. Nitroglycerin thymoma viral proto-oncogene 1 Mus musculus
3 The present study is to determine whether PI3K/Akt pathway in vascular smooth muscle cells is involved in nitroglycerin (NTG) tolerance and the underlying mechanism. Nitroglycerin thymoma viral proto-oncogene 1 Mus musculus
4 In conclusion, the present study suggests that PI3K/Akt in vascular smooth muscle is involved in the development of NTG tolerance via inhibiting PKG transcription and the effect is mediated by FoxO1. Nitroglycerin thymoma viral proto-oncogene 1 Mus musculus