Title : Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents.

Pub. Date : 2019 Mar

PMID : 30554080






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1 Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents. indole bromodomain containing 4 Homo sapiens
2 In this work, a series of indole derivatives that combine the inhibitory activities of BRD4 and HDAC into one molecule were designed and synthesized through the structure-based design method. indole bromodomain containing 4 Homo sapiens