Title : Loss of Adult 5-HT1A Autoreceptors Results in a Paradoxical Anxiogenic Response to Antidepressant Treatment.

Pub. Date : 2019 Feb 20

PMID : 30552180






1 Functional Relationships(s)
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1 These results suggest that markedly reduced 5-HT1A autoreceptors may provide a marker for aberrant response to SSRI treatment.SIGNIFICANCE STATEMENT Serotonin-selective reuptake inhibitors (SSRIs) are effective in treating anxiety and depression in humans and mouse models. Serotonin 5-hydroxytryptamine receptor 1A Homo sapiens