Title : Metformin inhibits estradiol and progesterone-induced decidualization of endometrial stromal cells by regulating expression of progesterone receptor, cytokines and matrix metalloproteinases.

Pub. Date : 2019 Jan

PMID : 30551411






2 Functional Relationships(s)
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Protein Name
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1 Metformin alleviated EP-triggered p38 MAPK inactivation and PGR (PGRA and PGRB) expression. Metformin mitogen-activated protein kinase 1 Homo sapiens
2 CONCLUSION: Metformin alleviated EP-induced decidualization of endometrial stromal cells by modulating secretion of multiple cytokines, inhibiting expression of MMP-2 and MMP-9, activating p38-MAPK signaling and reducing PGR expression, providing a deep insight into the molecular basis of metfromin therapy for PCOS patients. Metformin mitogen-activated protein kinase 1 Homo sapiens