Title : MicroRNA-128 targeting RPN2 inhibits cell proliferation and migration through the Akt-p53-cyclin pathway in colorectal cancer cells.

Pub. Date : 2018 Dec

PMID : 30546426






2 Functional Relationships(s)
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1 Markedly decreased Akt phosphorylation and cyclin D1 levels and increased p53 levels were detected when cells were transfected with miR-128 mimics. mir-128 AKT serine/threonine kinase 1 Homo sapiens
2 In conclusion, the results suggested that miR-128 was a specific negative regulator of RPN2, which regulated colorectal cancer cell proliferation and migration by affecting the Akt-p53-cyclin pathway. mir-128 AKT serine/threonine kinase 1 Homo sapiens