Pub. Date : 2018 Dec 9
PMID : 30544880
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway. | Naphthalimides | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Further analyses revealed a rapid and consistent activation of p38 signaling by the naphthalimide-NHC conjugates, with the Ru(II) analogue-termed MC6-showing the strongest effect. | Naphthalimides | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Altogether, our results provide new insight into the molecular mechanisms of naphthalimide-metal NHC analogues via the ROS-induced activation of p38 MAPK, which may have therapeutic interest for the treatment of various cancer types. | Naphthalimides | mitogen-activated protein kinase 14 | Homo sapiens |