Title : Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.

Pub. Date : 2018 Dec 11

PMID : 30540938






3 Functional Relationships(s)
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1 Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). Lactic Acid solute carrier family 16 member 1 Homo sapiens
2 Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). Lactic Acid solute carrier family 16 member 1 Homo sapiens
3 We report that syrosingopine, an anti-hypertensive drug, is a dual MCT1 and MCT4 inhibitor (with 60-fold higher potency on MCT4) that prevents lactate and H+ efflux. Lactic Acid solute carrier family 16 member 1 Homo sapiens