Pub. Date : 2019 Jan 15
PMID : 30538149
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS. | tert-Butylhydroperoxide | heme oxygenase 1 | Rattus norvegicus |
| 2 | During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS. | tert-Butylhydroperoxide | heme oxygenase 1 | Rattus norvegicus |
| 3 | HO-1 induction counteracted the oxidation of intracellular proteins and membrane lipids induced by tBuOOH, and fully prevented the increase in the oxidized-to-total glutathione (GSHt) ratio, a sensitive parameter of hepatocellular OS. | tert-Butylhydroperoxide | heme oxygenase 1 | Rattus norvegicus |