Pub. Date : 2018
PMID : 30537743
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sodium Fluoride Arrests Renal G2/M Phase Cell-Cycle Progression by Activating ATM-Chk2-P53/Cdc25C Signaling Pathway in Mice. | Sodium Fluoride | checkpoint kinase 2 | Mus musculus |
| 2 | CONCLUSION: In this mouse model, NaF, at more than 12 mg/ kg, induced G2/M phase cell-cycle arrest by activating the ATM-Chk2-p53/Cdc25C signaling pathway, which inhibits the proliferation of renal cells and development of the kidney. | Sodium Fluoride | checkpoint kinase 2 | Mus musculus |
| 3 | Activation of the ATM-Chk2-p53/Cdc25C signaling pathway is the mechanism of NaF-induced renal G2/M phase cell-cycle arrest in this model. | Sodium Fluoride | checkpoint kinase 2 | Mus musculus |