Title : Loperamide overcomes the resistance of colon cancer cells to bortezomib by inducing CHOP-mediated paraptosis-like cell death.

Pub. Date : 2019 Apr

PMID : 30529689






1 Functional Relationships(s)
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1 Furthermore, Lop potentiates Btz-mediated ER stress and ER dilation due to misfolded protein accumulation and Ca2+ imbalance, leading to CHOP upregulation and subsequent paraptosis-like cell death. Bortezomib DNA damage inducible transcript 3 Homo sapiens