Title : Self-glycerophospholipids activate murine phospholipid-reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading.

Pub. Date : 2019 Feb

PMID : 30508304






5 Functional Relationships(s)
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Protein Name
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1 Self-glycerophospholipids activate murine phospholipid-reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading. Glycerophospholipids CD1d1 antigen Mus musculus
2 Glycosphingolipids and glycerophospholipids bind CD1d. Glycerophospholipids CD1d1 antigen Mus musculus
3 Moreover, the increased flexibility of the two acyl chains in diacylglycerol ligands and a less stringent-binding orientation for glycerophospholipids as compared with the bindings of glycosphingolipids may allow glycerophospholipids to readily occupy CD1d. Glycerophospholipids CD1d1 antigen Mus musculus
4 Moreover, the increased flexibility of the two acyl chains in diacylglycerol ligands and a less stringent-binding orientation for glycerophospholipids as compared with the bindings of glycosphingolipids may allow glycerophospholipids to readily occupy CD1d. Glycerophospholipids CD1d1 antigen Mus musculus
5 Such superior ability of self-glycerophospholipids to compete with iNKT-cell ligands to occupy CD1d may help maintain homeostasis between the diverse subsets of lipid-reactive T cells, with important pathogenetic and therapeutic implications. Glycerophospholipids CD1d1 antigen Mus musculus