Pub. Date : 2018
PMID : 30504710
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In cooperation with the transmembrane protein Klotho, FGF23 is a powerful inhibitor of 1alpha 25OH Vitamin D Hydroxylase (Cyp27b1) and thus of the formation of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). | Calcitriol | fibroblast growth factor 23 | Homo sapiens |
| 2 | FGF23 formation and/or release are stimulated by 1,25(OH)2D3, phosphate excess, Ca2+, PTH, leptin, catecholamines, mineralocorticoids, volume depletion, lithium, high fat diet, iron deficiency, TNFalpha and TGFss2. | Calcitriol | fibroblast growth factor 23 | Homo sapiens |
| 3 | The case is made that up-regulation of FGF23 by inflammatory mediators and signaling may amplify inflammation by inhibiting formation of the anti-inflammatory 1,25(OH)2D3. | Calcitriol | fibroblast growth factor 23 | Homo sapiens |