Pub. Date : 2018
PMID : 30488759
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we mathematically modeled the recently dual-phase p53 dynamics under doxorubicin treatment. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 2 | We found that p53 could perform sequential pulses followed by a high-amplitude terminal pulse at relatively low doxorubicin treatment, whereas p53 became steadily accumulated when damage level was high. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 3 | Furthermore, lower binding affinity and degradation rate of p53 target genes could favorably discriminate high and low dose doxorubicin treatment. | Doxorubicin | tumor protein p53 | Homo sapiens |