Title : Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance.

Pub. Date : 2018 Nov 27

PMID : 30485823






1 Functional Relationships(s)
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1 Conversely, increased mitochondrial-H2O2 formation disrupts Akt1-mediated phosphorylation of Hsp70, and non-phosphorylatable Hsp70 mutants decrease SOD2 import, resulting in mitochondrial oxidative stress. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens