Pub. Date : 2019 Jan
PMID : 30483803
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It was demonstrated that U0126 significantly inhibited the proliferation, migration and collagen contraction of HTFs stimulated with TGF-beta1. | U 0126 | transforming growth factor beta 1 | Homo sapiens |
| 2 | In addition, U0126 largely attenuated the TGF-beta1-induced conversion of HTFs into myofibroblasts, as indicated by a downregulation of the mRNA and protein expression of alpha-smooth muscle actin and zinc finger protein SNAI1, and by ameliorating the 3D-collagen contraction response. | U 0126 | transforming growth factor beta 1 | Homo sapiens |
| 3 | Mechanistically, U0126 suppressed the TGF-beta1-stimulated phosphorylation of mothers against decapentaplegic homolog 2/3, P38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2, indicating that U0126 may inhibit HTF activation through the canonical and non-canonical signaling pathways of TGF-beta1. | U 0126 | transforming growth factor beta 1 | Homo sapiens |
| 4 | Mechanistically, U0126 suppressed the TGF-beta1-stimulated phosphorylation of mothers against decapentaplegic homolog 2/3, P38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2, indicating that U0126 may inhibit HTF activation through the canonical and non-canonical signaling pathways of TGF-beta1. | U 0126 | transforming growth factor beta 1 | Homo sapiens |
| 5 | Mechanistically, U0126 suppressed the TGF-beta1-stimulated phosphorylation of mothers against decapentaplegic homolog 2/3, P38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2, indicating that U0126 may inhibit HTF activation through the canonical and non-canonical signaling pathways of TGF-beta1. | U 0126 | transforming growth factor beta 1 | Homo sapiens |
| 6 | Mechanistically, U0126 suppressed the TGF-beta1-stimulated phosphorylation of mothers against decapentaplegic homolog 2/3, P38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2, indicating that U0126 may inhibit HTF activation through the canonical and non-canonical signaling pathways of TGF-beta1. | U 0126 | transforming growth factor beta 1 | Homo sapiens |