Title : Visfatin is regulated by interleukin‑6 and affected by the PPAR‑γ pathway in BeWo cells.

Pub. Date : 2019 Jan

PMID : 30483779






4 Functional Relationships(s)
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1 Activation of PPAR-gamma by pioglitazone resulted in significantly increased expression of visfatin, which abrogated the inhibitory effect of IL-6 on visfatin in BeWo cells. Pioglitazone nicotinamide phosphoribosyltransferase Homo sapiens
2 Activation of PPAR-gamma by pioglitazone resulted in significantly increased expression of visfatin, which abrogated the inhibitory effect of IL-6 on visfatin in BeWo cells. Pioglitazone nicotinamide phosphoribosyltransferase Homo sapiens
3 Furthermore, treatment using pioglitazone alone increased the expression and secretion of the visfatin protein, compared with the control or IL-6 alone group. Pioglitazone nicotinamide phosphoribosyltransferase Homo sapiens
4 Furthermore, thiazolidinedione pioglitazone, by upregulating visfatin expression, may promote the energy metabolism of trophoblastic cells, maintain the function of the placenta and improve the outcome of pregnancy. Pioglitazone nicotinamide phosphoribosyltransferase Homo sapiens