Title : PINK1 Protects Against Gentamicin-Induced Sensory Hair Cell Damage: Possible Relation to Induction of Autophagy and Inhibition of p53 Signal Pathway.

Pub. Date : 2018

PMID : 30483050






2 Functional Relationships(s)
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1 We found that treatment of 400 muM GM elicited the formation of ROS, which, in turn, led to PINK1 degradation, parkin recruitment, autophagy formation, an increase of p53 and cleaved-caspase 3 in HEI-OC1 cells and murine HCs. Reactive Oxygen Species tumor protein p53 Homo sapiens
2 In contrast, co-treatment with ROS scavenger N-acetyl-L-cysteine (NAC) inhibited parkin recruitment, alleviated autophagy and p53 pathway-related damaged-cell elimination. Reactive Oxygen Species tumor protein p53 Homo sapiens