Pub. Date : 2018 Nov 27
PMID : 30482227
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: IFN-alpha down-regulated the cyclooxygenase-2 (COX-2) expression in bladder cancer cells through the inhibition of TPL2/NF-kappaB pathway; IFN-alpha also inhibited COX-2 expression by suppressing cAMP signaling through TPL2-ERK mediated PDE4D activity. | Cyclic AMP | interferon alpha 1 | Homo sapiens |
| 2 | RESULTS: IFN-alpha down-regulated the cyclooxygenase-2 (COX-2) expression in bladder cancer cells through the inhibition of TPL2/NF-kappaB pathway; IFN-alpha also inhibited COX-2 expression by suppressing cAMP signaling through TPL2-ERK mediated PDE4D activity. | Cyclic AMP | interferon alpha 1 | Homo sapiens |
| 3 | Reduction of the intracellular cAMP level by PDE4D potentiated the antitumor effect of IFN-alpha against bladder cancer in vitro and in vivo. | Cyclic AMP | interferon alpha 1 | Homo sapiens |
| 4 | The antitumor effects of IFN-alpha and MEK inhibition also depend on the PDE4D-mediated cAMP level in bladder cancer cells. | Cyclic AMP | interferon alpha 1 | Homo sapiens |
| 5 | Suppression of the TPL2 phosphorylation and intracellular cAMP level may be possible therapeutic strategies for enhancing the effectiveness of IFN-alpha and MEK inhibitors in bladder cancer treatment. | Cyclic AMP | interferon alpha 1 | Homo sapiens |