Title : Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition.

Pub. Date : 2018 Dec 27

PMID : 30481027






1 Functional Relationships(s)
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1 Among these analogues, 15n with tetrazole in place of 1,2,4-triazole exhibited optimal inhibition of human umbilical vein endothelial cell proliferation with an IC50 of 73 nM without a significant effect on CYP3A4 (EC50 > 20 muM). 15n cytochrome P450 family 3 subfamily A member 4 Homo sapiens