Title : Role of MCP-1 and CCR2 in alcohol neurotoxicity.

Pub. Date : 2019 Jan

PMID : 30472461






5 Functional Relationships(s)
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1 Recent evidence indicates that alcohol exposure increased the activity of MCP-1/CCR2 in both mature and developing central nervous systems (CNS). Alcohols C-C motif chemokine ligand 2 Homo sapiens
2 MCP-1/CCR2 signaling in the brain was involved in alcohol drinking behavior. Alcohols C-C motif chemokine ligand 2 Homo sapiens
3 MCP-1/CCR2 inhibition alleviated alcohol neurotoxicity by reducing microglia activation/neuroinflammation in the developing brain and spinal cord. Alcohols C-C motif chemokine ligand 2 Homo sapiens
4 In this review, we discussed the role of MCP-1/CCR2 signaling in alcohol-induced neuroinflammation and brain damage. Alcohols C-C motif chemokine ligand 2 Homo sapiens
5 We also discussed the signaling cascades that are involved in the activation of MCP-1/CCR2 in response to alcohol exposure. Alcohols C-C motif chemokine ligand 2 Homo sapiens