Title : Conversion from Twice-Daily Prograf® to Once-Daily Advagraf® in Multi-ethnic Asian Adult Renal Transplant Recipients With or Without Concomitant Use of Diltiazem: Impact of CYP3A5 and MDR1 Genetic Polymorphisms on Tacrolimus Exposure.

Pub. Date : 2019 Aug

PMID : 30471066






1 Functional Relationships(s)
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1 In contrast, among CYP3A5 expressors receiving diltiazem, AUCss, 0-24 did not change significantly upon conversion [229 (170-296) vs. 221 (123-342) ng h/mL, p = 0.575, n = 10]. Diltiazem cytochrome P450 family 3 subfamily A member 5 Homo sapiens