Pub. Date : 2018 Nov 22
PMID : 30466442
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To date, this is the most credited mechanism of action of BET inhibitors, a class of small molecules targeting BET proteins which are currently in clinical trials in several cancer settings.However, recent evidence indicates that BRD4 relevance in cancer goes beyond its role in transcription regulation and identifies this protein as a keeper of genome stability.Indeed, a non-transcriptional role of BRD4 in controlling DNA damage checkpoint activation and repair as well as telomere maintenance has been proposed, throwing new lights into the multiple functions of this protein and opening new perspectives on the use of BETi in cancer. | beti | bromodomain containing 4 | Homo sapiens |
| 2 | Furthermore, in light of the transversal function of BRD4, we provide new interpretation for the cytotoxic activity of BETi and we discuss new possibilities for a wide and focused employment of these drugs in clinical settings. | beti | bromodomain containing 4 | Homo sapiens |