Title : Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway.

Pub. Date : 2019 Apr

PMID : 30456590






1 Functional Relationships(s)
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1 H2O2 treated cells showed characteristic senescence-associated features including increased cell size, senescence-associated beta-galactosidase activity (SA-beta-gal), development of senescence-associated secretory phenotype (SASP), activation of reactive oxygen species (ROS) and pathways, DNA damage as well as induction of cell cycle inhibitors (p53/p21WAF1/p16INK4a). Hydrogen Peroxide tumor protein p53 Homo sapiens