Title : PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes.

Pub. Date : 2019 Jan

PMID : 30453390






2 Functional Relationships(s)
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1 GW0742 enhanced the expression of CPT1a, the gene encoding for a rate-limiting enzyme of fatty acid oxidation. GW0742 carnitine palmitoyltransferase 1a, liver Mus musculus
2 Similarly, treatment of a mouse model of AD, the APP/PS1-mice, with GW0742 increased the expression of Cpt1a and concomitantly reversed memory deficits in a fear conditioning test. GW0742 carnitine palmitoyltransferase 1a, liver Mus musculus