Title : Fibroblast growth factor 23 and α-Klotho co-dependent and independent functions.

Pub. Date : 2019 Jan

PMID : 30451736






1 Functional Relationships(s)
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1 Local and systemic factors control FGF-23 release from osteoblast/osteocytes in bone, and circulating FGF-23 activates FGFR/alpha-Klotho complexes in kidney proximal and distal renal tubules to regulate renal phosphate excretion, 1,25 (OH)2D metabolism, sodium and calcium reabsorption, and ACE2 and alpha-Klotho expression. Phosphates klotho Homo sapiens