Pub. Date : 2019 Jan
PMID : 30451372
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Urokinase + tranexamic acid produces plasmin in plasma or blood and disrupts clotting. | Tranexamic Acid | plasminogen | Homo sapiens |
| 2 | Results IC50 values for antifibrinolytic activity of TXA varied from < 10 to > 1000 mumol L-1 depending on the system, but good fibrin protection was observed in the presence of tPA, uPA and plasmin. | Tranexamic Acid | plasminogen | Homo sapiens |
| 3 | However, in plasma or blood, active plasmin was generated by TXA + uPA (but not tPA) and coagulopathy developed leading to no or poor clot formation. | Tranexamic Acid | plasminogen | Homo sapiens |
| 4 | Conclusions Tranexamic acid protects fibrin but stimulates uPA activity and slows inhibition of plasmin by alpha2 -antiplasmin. | Tranexamic Acid | plasminogen | Homo sapiens |
| 5 | Additional direct inhibition of plasmin by aprotinin may prevent development of coagulopathy and extend the useful time window of TXA treatment. | Tranexamic Acid | plasminogen | Homo sapiens |