Title : Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450.

Pub. Date : 1988 Sep

PMID : 3044903






7 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450. Heme cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Porphyrinogenic chemicals deplete the regulatory free heme pool by interacting with cytochrome P-450 thereby inhibiting heme biosynthesis and/or causing heme breakdown. Heme cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 Porphyrinogenic chemicals deplete the regulatory free heme pool by interacting with cytochrome P-450 thereby inhibiting heme biosynthesis and/or causing heme breakdown. Heme cytochrome P450 family 4 subfamily F member 3 Homo sapiens
4 Porphyrinogenic chemicals deplete the regulatory free heme pool by interacting with cytochrome P-450 thereby inhibiting heme biosynthesis and/or causing heme breakdown. Heme cytochrome P450 family 4 subfamily F member 3 Homo sapiens
5 Heterocyclic compounds of this type cause mechanism-based inactivation of cytochrome P-450, leading to the formation of N-alkylporphyrins, with ferrochelatase-inhibitory activity resulting in lowering the free heme pool. Heme cytochrome P450 family 4 subfamily F member 3 Homo sapiens
6 In the process, the heme moiety of cytochrome P-450 is destroyed and the free heme pool is lowered. Heme cytochrome P450 family 4 subfamily F member 3 Homo sapiens
7 In the process, the heme moiety of cytochrome P-450 is destroyed and the free heme pool is lowered. Heme cytochrome P450 family 4 subfamily F member 3 Homo sapiens