Pub. Date : 1988 Sep
PMID : 3044903
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450. | Heme | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | Porphyrinogenic chemicals deplete the regulatory free heme pool by interacting with cytochrome P-450 thereby inhibiting heme biosynthesis and/or causing heme breakdown. | Heme | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | Porphyrinogenic chemicals deplete the regulatory free heme pool by interacting with cytochrome P-450 thereby inhibiting heme biosynthesis and/or causing heme breakdown. | Heme | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | Porphyrinogenic chemicals deplete the regulatory free heme pool by interacting with cytochrome P-450 thereby inhibiting heme biosynthesis and/or causing heme breakdown. | Heme | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | Heterocyclic compounds of this type cause mechanism-based inactivation of cytochrome P-450, leading to the formation of N-alkylporphyrins, with ferrochelatase-inhibitory activity resulting in lowering the free heme pool. | Heme | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 6 | In the process, the heme moiety of cytochrome P-450 is destroyed and the free heme pool is lowered. | Heme | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 7 | In the process, the heme moiety of cytochrome P-450 is destroyed and the free heme pool is lowered. | Heme | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |