Pub. Date : 2018 Nov 15
PMID : 30442142
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin causes cancer cell death through downregulation of p53-dependent differentiated embryo chondrocyte 1. | Metformin | tumor protein p53 | Homo sapiens |
| 2 | We later clarified the effect of metformin on p53 protein stability using transient transfection and cycloheximide chase analyses. | Metformin | tumor protein p53 | Homo sapiens |
| 3 | RESULTS: We observed that metformin represses cell cycle progression, thereby inducing subG1 populations, and had induced apoptosis through downregulation of p53 protein and a target gene, differentiated embryo chondrocyte 1 (DEC1). | Metformin | tumor protein p53 | Homo sapiens |
| 4 | Examination of the mechanisms underlying metformin-induced HeLa cell death revealed that reduced stability of p53 in metformin-treated cells leads to decreases in DEC1 and induction of apoptosis. | Metformin | tumor protein p53 | Homo sapiens |
| 5 | Examination of the mechanisms underlying metformin-induced HeLa cell death revealed that reduced stability of p53 in metformin-treated cells leads to decreases in DEC1 and induction of apoptosis. | Metformin | tumor protein p53 | Homo sapiens |
| 6 | CONCLUSION: The involvement of DEC1 provides new insight into the positive or negative functional roles of p53 in the metformin-induced cytotoxicity in tumor cells. | Metformin | tumor protein p53 | Homo sapiens |