Pub. Date : 2019 Apr
PMID : 30431692
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway. | fisetin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Our results depicted that fisetin induced apoptosis of these cells by various mechanisms, such as inactivation of the receptor, induction of proteasomal degradation, decreasing its half-life, decreasing enolase phosphorylation, and alteration of phosphatidylinositol 3-kinase/Akt signaling. | fisetin | AKT serine/threonine kinase 1 | Homo sapiens |