Title : Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway.

Pub. Date : 2019 Apr

PMID : 30431692






2 Functional Relationships(s)
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1 Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway. fisetin AKT serine/threonine kinase 1 Homo sapiens
2 Our results depicted that fisetin induced apoptosis of these cells by various mechanisms, such as inactivation of the receptor, induction of proteasomal degradation, decreasing its half-life, decreasing enolase phosphorylation, and alteration of phosphatidylinositol 3-kinase/Akt signaling. fisetin AKT serine/threonine kinase 1 Homo sapiens