Pub. Date : 2018 Nov 14
PMID : 30429460
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we found 14,15-epoxyeicosatrienoic acid (14,15-EET), a cytochrome P450 (CYP) metabolite, from hUCB-MSCs and the cerebella of NPC1-mutant mice and investigated the functional consequence of this metabolite. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Here, we found 14,15-epoxyeicosatrienoic acid (14,15-EET), a cytochrome P450 (CYP) metabolite, from hUCB-MSCs and the cerebella of NPC1-mutant mice and investigated the functional consequence of this metabolite. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Here, we found 14,15-epoxyeicosatrienoic acid (14,15-EET), a cytochrome P450 (CYP) metabolite, from hUCB-MSCs and the cerebella of NPC1-mutant mice and investigated the functional consequence of this metabolite. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 4 | Here, we found 14,15-epoxyeicosatrienoic acid (14,15-EET), a cytochrome P450 (CYP) metabolite, from hUCB-MSCs and the cerebella of NPC1-mutant mice and investigated the functional consequence of this metabolite. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 5 | In this regard, we found that one CYP metabolite, 14,15-EET, acts as a key mediator in ameliorating cholesterol accumulation. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 6 | We show that the reduced activity within the CYP system in the cerebellum could cause the neurological symptoms of NPC1 patients, as 14,15-EET treatment significantly rescued cholesterol accumulation and impaired autophagy. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |