Title : Granulocyte-macrophage colony-stimulating factor regulation in murine T cells and its relation to cyclosporin A.

Pub. Date : 1988 Sep

PMID : 3042442






4 Functional Relationships(s)
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1 CsA did not affect the kinetics of GM-CSF release, but inhibited the release of IL3 over a period of 40 h after the cells were stimulated and treated with CsA. Cyclosporine interleukin 3 Mus musculus
2 CsA did not affect the kinetics of GM-CSF release, but inhibited the release of IL3 over a period of 40 h after the cells were stimulated and treated with CsA. Cyclosporine interleukin 3 Mus musculus
3 In addition, CsA could be added up to 1 h after stimulation of the cells without affecting GM-CSF activity but inhibiting completely the IL3 activity. Cyclosporine interleukin 3 Mus musculus
4 The data reveal that CsA can dissociate between the production of IL3 and GM-CSF, suggesting that these two CSFs are regulated by different mechanisms. Cyclosporine interleukin 3 Mus musculus