Pub. Date : 2019 Feb
PMID : 30422809
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antitumor effects of beta-elemene via targeting the phosphorylation of insulin receptor. | beta-elemene | insulin receptor | Homo sapiens |
| 2 | To investigate the mechanisms, we focused on the effects of beta-elemene on IR signaling pathway. | beta-elemene | insulin receptor | Homo sapiens |
| 3 | Further, the phosphorylation of IR was found to be suppressed notably by beta-elemene specifically in tumor cells but not normal hepatocytes. | beta-elemene | insulin receptor | Homo sapiens |
| 4 | In addition, beta-elemene inhibited the growth of ESFT xenografts in vivo, and the phosphorylation of IR and S6 ribosomal protein was significantly repressed in the beta-elemene-treated xenografts. | beta-elemene | insulin receptor | Homo sapiens |
| 5 | These data suggest that beta-elemene targets IR phosphorylation to inhibit the proliferation of tumor cells specifically and enhace the effects of IGF1R inhibitors. | beta-elemene | insulin receptor | Homo sapiens |