Title : Pinellia pedatisecta lectin exerts a proinflammatory activity correlated with ROS-MAPKs/NF-κB pathways and the NLRP3 inflammasome in RAW264.7 cells accompanied by cell pyroptosis.

Pub. Date : 2019 Jan

PMID : 30415189






2 Functional Relationships(s)
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1 PPL decreased the mitochondrial membrane potential (MMP) and increased the outflow of calcium, accompanied by the overproduction of reactive oxygen species (ROS), which resulted in the activation of the MAPK and NF-kappaB pathways and the release of IL-1beta. Reactive Oxygen Species interleukin 1 beta Mus musculus
2 Further, we found that N-acetylcysteine (NAC), an ROS scavenger, could inhibit the PPL-stimulated activation of these pathways and the release of IL-1beta. Reactive Oxygen Species interleukin 1 beta Mus musculus