Title : Spirocyclohexadienones as an Uncommon Scaffold for Acetylcholinesterase Inhibitory Activity.

Pub. Date : 2019

PMID : 30411689






1 Functional Relationships(s)
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1 Molecular docking study indicated that the spirocyclohexadienone, 9e (IC50 = 0.12 microM), a mixedtype AChE inhibitor, showed a good interaction at active site of the enzyme, including the cationic (CAS) and the peripheral site (PAS). Calcium acetylcholinesterase (Cartwright blood group) Homo sapiens