Title : HMGB1 Antagonist, Box A, Reduces TLR4, RAGE, and Inflammatory Cytokines in the Cornea of P. aeruginosa-Infected Mice.

Pub. Date : 2018 Nov 8

PMID : 30407111






2 Functional Relationships(s)
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1 RESULTS: Box A versus PBS prophylactic treatment significantly reduced clinical scores, MPO activity, bacterial load, and expression of TLR4, RAGE, IL-1beta, CXCL2, and TNF-alpha in the infected cornea. pbs interleukin 1 beta Mus musculus
2 Box A versus PBS therapeutic treatment significantly reduced clinical scores, MPO activity, bacterial load, and protein levels of IL-1beta, CXCL2, and IL-6 in the infected cornea. pbs interleukin 1 beta Mus musculus