Pub. Date : 2018 Nov
PMID : 30405800
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low dose dinaciclib enhances doxorubicin-induced senescence in myeloma RPMI8226 cells by transformation of the p21 and p16 pathways. | dinaciclib | H3 histone pseudogene 16 | Homo sapiens |
| 2 | Notably, the combination of dinaciclib and DOX inhibited cell growth and promoted senescence by transforming the suppressive effects of the ATM/Chk2/p53/p21 signaling pathway and enhancing the p16 signaling pathway. | dinaciclib | H3 histone pseudogene 16 | Homo sapiens |
| 3 | Thus, low-dose dinaciclib enhanced anti-MM effects mediated by DOX via transformation of p21-p16 signaling pathways, leading to accelerated senescence, but not apoptosis. | dinaciclib | H3 histone pseudogene 16 | Homo sapiens |